TCL38 resource portal
A Multi-Omics Resource for T-Cell Lymphomas 
The resource provides integrated RNA-seq, ATAC-seq, aCGH, single-drug and combination sensitivity data from 38 T-cell lymphoma cell lines across major clinical T-cell lymphoma subtypes.
Partner Institutions
This research represents a collaborative effort across multiple institutions in cancer research and precision medicine, bringing together expertise from universities and research centers across Europe and North America.
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General Question
This dataset includes harmonised genetic, molecular and epigenetic data, with comprehensive annotations, and standardised drug response assessment of the cell lines, representing major clinical T-cell lymphoma and leukemia (TCL) subtypes and capturing the molecular and phenotypic diversity of TCLs. This dataset supports investigations into TCL subtype-specific therapeutic vulnerabilities linked to genetic and epignenetic features.
The complete dataset can be downloaded through Orcestra platform: https://www.orcestra.ca/pset/675c3be4136b907873280cb8, which also includes information on data processing and exact algorithms/methods used.
Alternatively, the data can be downloaded though Zenodo: https://zenodo.org/records/14733210
Alternatively, the data can be downloaded though Zenodo: https://zenodo.org/records/14733210
Ianevski, Aleksandr, et al. “Multi-omics Profiling of T-cell Leukemia and Lymphoma Enables Targeted Therapeutic Discovery.”
Cancer Research (2025).
https://doi.org/10.1158/0008-5472.CAN-25-0881